Exogenous itaconate addition in apolipoprotein E-deficient (Apoe−/−) mice suppressed the initiation and progression of AAA and downstream inflammatory protein when Irg1 deficiency reverted the outcome of inhibitory. Overexpression of Keap1 or transferred Cys151S mutant Keap1 vector also abolished the activation of Nrf2 induced by itaconate. Above 600 proteins are targets https://xp-5992345.digitollblog.com/29545622/wedelolactone-for-dummies