Chemotherapy was potentiated by E7449 and solitary agent experienced substantial antitumor activity in BRCA-deficient xenografts. Furthermore, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell traces, probable by TNKS inhibition. Consistent with this probability, E7449 stabilized axin and TNKS proteins leading to β-catenin de-stabilization and drastically altered expression... https://kirkx863otx7.blogdemls.com/profile