Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals through the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific tests have determined recurrent mutations in genes regulating tumor mobile-microenvironment int... https://johnr752pxe0.daneblogger.com/profile