There exists a release of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors while in the dorsal horn to decrease afferent pain transmission and make analgesia. For that reason, medicines like clonidine that target alpha-2 receptors can influence the transmission of agony. Applies to clonidine: oral https://prbookmarkingwebsites.com/story24080480/onolidine-an-overview